According to the revised Regulation of Pesticide Administration approved in February 2017 by the State Council, the Ministry of Agriculture and Rural Affairs (MARA) is in charge of the pesticide management in China. The MARA has established a more stringent threshold for pesticide registration, in which risk assessment is a necessary process of evaluation, and the temporary registration has been abolished since June 2017.

The avermectins are derived from a family of macrocyclic lactones produced by the soil microorganism Streptomyces avermitilis. Abamectin (avermectin B1) was introduced in 1985 as a crop insecticide against mites and some insect species. The semisynthetic derivative ivermectin (22,23-dihydroavermectin B1) was introduced commercially in 1981 as an anthelmintic. T

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