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The avermectins are derived from a family of macrocyclic lactones produced by the soil microorganism Streptomyces avermitilis. Abamectin (avermectin B1) was introduced in 1985 as a crop insecticide against mites and some insect species. The semisynthetic derivative ivermectin (22,23-dihydroavermectin B1) was introduced commercially in 1981 as an anthelmintic. T

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